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Updated: Jul 11, 2025

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针对B细胞中的NF-κB信号传递作为ANCA相关血管炎的潜在新治疗方式

Ana Merino-Vico1, Jan Piet van Hamburg1, Paul Tuijnenburg2

  • 1Department of Rheumatology and Clinical Immunology, Amsterdam Rheumatology and immunology Center, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands; Department of Experimental Immunology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.

Journal of autoimmunity
|November 6, 2023
PubMed
概括

针对B细胞中NF-κB信号通路的新疗法对ANCA相关血管炎 (AAV) 有前途. 抑制NF-κB诱导激酶 (NIK) 和IKKβ有效降低了AAV患者的B细胞活性和自身抗体的产生.

关键词:
在 AAV AAV AAV 中.B 细胞细胞B 细胞细胞CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40 CD40在 NF-κBB 中.尼克尼克尼克是什么意思细胞等离子体细胞

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