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Updated: Jul 11, 2025

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功能激活PD-1+CD8+细胞的致病性以及肌肉PD-L1通过IFNγ在肌肉炎中的反击

Hirokazu Sasaki1, Natsuka Umezawa1, Takuji Itakura1

  • 1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Journal of autoimmunity
|November 6, 2023
PubMed
概括

编程细胞死亡1 (PD-1) + CD8+ T细胞在异常发炎性肌肉病变 (IIM) 中具有病原性. 这些细胞,表达细胞分解分子和TOX,驱动IIM病理,而PD-L1提供保护.

关键词:
IFNγ IFNγ 的意思是异形性炎症性肌肉病变是一种异形性炎症性肌肉病变.编程细胞死亡1 (PD-1) 编程细胞死亡编程细胞死亡1连接物1 (PD-L1)T细胞耗尽的情况

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