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位于墨西哥尤卡坦州的瑞克症的临床和实验室特征

Karla Dzul-Rosado¹, Candi Panti-Balam¹, Dayana Lavín-Sánchez¹

¹Dr. Hideyo Noguchi Regional Research Center, Emerging and Re-emerging Disease Laboratory, Avenida Itzáes, No 490 x Calle 59, Col. Centro, CP 97000, Autonomous University of Yucatan, Merida, Yucatan 97000, Mexico.

|November 6, 2023

概括

包括伤寒和斑点发烧群体在内的瑞克特病在墨西哥尤卡坦岛是特有的. 分子诊断证实了22.7%的病例,强调需要提高疾病意识和预防策略.

科学领域:

医学微生物学医学微生物学
传染性疾病传染性疾病
分子诊断学分子诊断

背景情况:

里克特西亚种类导致人类疾病的范围,从轻度到致命的发烧性疾病.
将它们分为四组是基于植物遗传,临床症状和抗原性质.
里克塞索病毒感染取决于具体的物种,宿主因素和及时的医疗干预.

研究的目的:

为了描述墨西哥尤卡坦州的瑞克特病.
分析已确认的瑞克菌感染的临床和实验室特征.
评估瑞克特西亚物种的流行和分布.

主要方法:

从2015年至2018年对427名患者的病历进行了回顾性分析.
用基因特异性PCR对瑞克塞17kDa和OmpB基因进行分子诊断.
用于物种识别的PCR amplicon的净化和测序.

主要成果:

22.7% (97/427) 的样本检测出Rickettsia物种的阳性.
大多数病例 (75.2%) 在秋季期间在梅里达被发现.
儿科 (5-14岁) 和成人 (25-49岁) 年龄组显示的频率最高;发生了6起儿科死亡.
确定了伤寒症组 (60.8%) 和斑点发烧组 (32.9%) 的病.

结论:

里克特西亚物种,包括伤寒和斑点发烧群,是尤卡坦岛的特有物种.
分子识别可以提高诊断准确度和治疗结果.
专注于瑞克病意识和预防的公共卫生举措至关重要.

关键词:

临床临床临床临床实验室实验室实验室实验室里克特西亚 (Rickettsia) 是一个古老的植物.

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