在急性髓性白血病中,中央糖尿病无味和部分前垂体功能障碍
Rigya Arya1, Tehmina Ahmad2, Satya Dash2,3
1Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Endocrinology, diabetes & metabolism case reports
|November 6, 2023
概括
在急性骨髓性白血病 (AML) 中,中部无味糖尿病 (CDI) 可能是由白血病透引起的. 这一案例突出显示了在AML中患有下垂体功能障碍的CDI,使用德斯莫普林素进行治疗.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 神经学 神经学
背景情况:
- 中心无味糖尿病 (CDI) 是急性髓性白血病 (AML) 的一种罕见表现.
- 以前的病例往往缺乏脑成像异常和特定的染色体异常.
- 在AML中CDI的病因尚不清楚.
研究的目的:
- 在一个新诊断AML的患者中呈现CDI和部分前垂体功能障碍的独特病例.
- 在AML和异常大脑成像的背景下调查CDI的潜在原因.
- 描述这个罕见的演示的管理和结果.
主要方法:
- 一名新诊断出AML的女性患者的病例报告 t(12;14)
- 临床评估包括血清电解质,度和尿液度.
- 大脑MRI用于评估中枢神经系统的参与.
- 下垂体激素小组评估.
- 使用静脉注射德斯莫普林的治疗.
主要成果:
- 患者呈现出多尿症和多滴水症的症状,诊断为CDI.
- 生物化学揭示了高血和不适当稀释的尿液.
- 大脑MRI显示了下丘脑异常,部分空,以及缺陷的垂体亮点的损失.
- 部分前垂体功能障碍被证实.
- 德斯摩素治疗有效地管理了DI,并纠正了高血量.
结论:
- 这种情况表明白血病透于下丘脑是导致CDI和AML部分前垂体功能障碍的原因.
- 异常的大脑成像可能存在于AML相关的CDI中.
- 德斯莫普雷辛是一种有效的治疗AML相关的CDI,可能独立于AML治疗反应.
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