在精神分裂症中,胆-白质-皮质电路的结构功能连接缺陷
Pan Wang1, Yuan Jiang1, Matthew J Hoptman2
1MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.
Psychiatry research
|November 6, 2023
概括
精神分裂症涉及大脑网络连接的改变,特别是在白质 (WM) 途径中. 这项研究揭示了状-WM-皮质电路中的异常连接,为精神分裂症症状提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 精神分裂症的特征是大规模的功能网络集成和皮层-皮层下通道通信中断.
- 白质 (WM) 纤维束对于长距离信息传输至关重要,它们的功能信号反映了神经活动.
- 深层状组织在调节精神分裂症中通过WM调节皮质活动中的特定作用仍然不太清楚.
研究的目的:
- 调查精神分裂症患者中索-WM-皮质回路的结构和功能连接性变化.
- 确定特定的WM和灰色物质 (GM) 功能网络和质体子区域,涉及这些变化.
- 探索这些连接缺陷与精神分裂症的核心症状之间的关系.
主要方法:
- 利用数据驱动的方法来识别九个WM和GM功能网络.
- 将体分成不同的子区域.
- 组合功能连接和扩散张力成像 (DTI) 纤维跟踪分析以评估结构和功能连接.
主要成果:
- 与健康对照人群相比,在精神分裂症患者中观察到体,WM和GM网络之间的结构和功能连接性显著更高.
- 识别了与视觉处理,执行控制,突出检测和情绪处理相关的网络中的变化.
- 在callosal-WM-皮质电路中发现了九条异常路径,包括涉及默认模式网络的路径.
结论:
- 脊髓-WM-皮质回路的连接缺陷与精神分裂症有关.
- 这些发现为理解精神分裂症中的妄想,幻觉和认知障碍提供了神经生物学基础.
- 强调研究WM完整性及其在精神疾病中大脑网络通信中的作用的重要性.
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