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多发性硬化症视力问卷 (MSVQ-7):可靠性,有效性,精度和歧视性.

Carolyn A Young1, David J Rog2, Radu Tanasescu3

  • 1Molecular and Integrative Biology, Institute of Systems, University of Liverpool, Liverpool, United Kingdom; Walton Centre NHS Foundation Trust, Liverpool, United Kingdom.

Multiple sclerosis and related disorders
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概括

多发性硬化症视力问卷 (MSVQ-7) 是评估多发性硬化症患者视力问题的可靠工具. 它随着时间的推移显示出显著的变化,并且与抑郁和耻辱有很强的相关性.

关键词:
抑郁症 抑郁症 抑郁症我们的MSVQ-7是MSVQ-7拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什拉什神经系统疾病的结果轨迹-MS视觉 视觉 视觉 视觉 视觉 是一个

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科学领域:

  • 眼科医生 眼科 眼科
  • 神经学 神经学
  • 心理测量 心理测量 心理测量

背景情况:

  • 视觉功能障碍是患有多发性硬化症 (pwMS) 的患者普遍和复杂的问题.
  • 现有的捕捉患者视觉病理体验的方法具有挑战性.
  • 需要一个经过验证,可靠的患者报告的措施来获得临床和研究的好处.

研究的目的:

  • 在大量多发性硬化症 (MS) 患者群体中检查MS视觉问卷 (MSVQ-7) 的心理测量特性.
  • 评估MSVQ-7检测视力问题的临床显著变化随着时间的推移的能力.
  • 探索视觉功能障碍与其他因素 (如抑郁,焦虑和pwMS中的耻辱) 之间的关系.

主要方法:

  • 利用了来自全英国神经疾病-MS (TONiC-MS) 研究结果轨迹的数据.
  • 在1000 pwMS的校准样本上进行了确认因素分析和拉什分析.
  • 使用基于的方法计算最小可检测变化 (MDC) 和最小临床重要变化 (MIC).

主要成果:

  • MSVQ-7 证明了单维性,并符合拉什模型,允许转换为间隔级度量.
  • 在5478名pwMS中,80%的人报告视力问题,分数因MS亚型而异,随着时间的推移而改变.
  • 超过四分之一的随访样本报告了MSVQ-7得分的临床显著变化;视力问题强烈预测了抑郁风险.

结论:

  • MSVQ-7是一个精确而有区别的简短自我报告措施,用于pwMS的视觉问题.
  • 视力问题很常见,随着时间的推移而变化,并显著影响抑郁症风险和耻辱感.
  • MSVQ-7表现出强大的心理测量特性,支持其在临床和研究环境中采用用于常规视觉评估.