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在SPIROMICS中肺部结构和睡眠呼吸暂停的风险
Abigail L Koch1, Tracie L Shing2, Andrew Namen3
1Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States.
Chronic obstructive pulmonary diseases (Miami, Fla.)
|November 6, 2023
概括
肺功能减弱与吸烟者患阻塞性睡眠呼吸暂停 (OSA) 的风险更高有关. 肺部结构,包括气道尺寸,进一步影响了这一关联,突出了干预的潜在目标.
科学领域:
- 肺部医学 肺部医学
- 睡眠医学 睡眠医学
- 放射学 放射学是一门学科.
背景情况:
- 慢性阻塞性肺病 (COPD) 和阻塞性睡眠呼吸暂停 (OSA) 经常同时存在,恶化患者的生活质量和恶化频率.
- 在CT扫描中,COPD的严重程度与肺气和气道尺寸改变有关.
研究的目的:
- 调查肺功能和肺结构对目前和前吸烟者的OSA风险的综合影响.
- 确定特定的肺结构参数来改变肺功能与OSA风险之间的关联.
主要方法:
- 利用了SPIROMICS队列中的1767名当前和前吸烟者的数据.
- 使用柏林睡眠问卷 (BSQ) 和DOISNORE50 (DIS) 评分来评估OSA风险.
- 分析了肺功能 (预测FEV1%) 与OSA风险之间的关联,并根据肺结构指标进行调整 (例如,肺气,呼吸道尺寸,呼吸障碍).
主要成果:
- 预测FEV1%的10%降低与高OSA风险的几率增加有关 (DIS:OR=1.09;BSQ:OR=1.04).
- 在调整了肺结构后,这些关联仍然很重要.
- 发现特定的肺部结构元素,包括无呼吸症,功能性小呼吸道疾病和气管壁区域,加强了肺功能和OSA风险之间的联系.
结论:
- 肺功能下降独立预测吸烟者有更高的OSA风险.
- 肺部结构特征在调节这一群体的OSA风险方面发挥着至关重要的作用.
- 研究结果表明,在吸烟者的OSA管理中,肺功能和肺结构的综合评估有潜力.
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