吸入器配方COPD的变化以及与恶化,医疗保健利用和成本的关联
Kevin I Duan1,2, Lucas M Donovan2,3, Laura J Spece2,3
1Division of Respiratory Medicine, University of British Columbia, Vancouver, Canada.
Chronic obstructive pulmonary diseases (Miami, Fla.)
|November 6, 2023
概括
由于配方改变而非医疗转换COPD吸入器并没有影响退伍军人的恶化或医疗费用. 需要对严重疾病和其他环境进行进一步研究.
科学领域:
- 肺部医学 肺部医学
- 医疗保健服务研究 医疗服务研究
- 药物经济学 药物经济学
背景情况:
- 处方配方剂决定了药物的可用性,频繁的变化可能需要非医疗切换.
- 非医疗转换与疾病控制和坚持性降低有关,但其对COPD的影响尚未得到充分研究.
- 形式的变化可能会影响COPD等慢性疾病的患者治疗计划.
研究的目的:
- 评估表格变化对COPD恶化,医疗保健接触和成本的影响.
- 研究使用吸入器治疗的COPD退伍军人非医疗转换的后果.
- 评估从国家表单中删除formoterol与患者结局之间的关联.
主要方法:
- 对使用吸入器治疗的10,606名患有COPD的退伍军人进行了队列研究.
- 一个2点差异分析分析了6个月前和6个月后的结果,以消除formoterol的配方.
- 结果包括COPD恶化,总体医疗保健遭遇和相关成本.
主要成果:
- 3.9%的符合条件的退伍军人 (409) 由于表格变化而更换了吸入器.
- 没有观察到COPD恶化的显著变化 ( -0.04恶化;95%CI -0.12,0.03).
- 二次结果也显示,医疗保健遭遇或成本没有显著变化.
结论:
- 由于配方药中断而转换非医疗吸入器与COPD恶化,遭遇或成本的变化无关.
- 研究结果表明,对于一些COPD患者来说,以配方驱动的非医疗转换可能不会显著改变关键的临床或经济结果.
- 建议进行进一步的研究,以验证这些发现在更严重的COPD病例和各种医疗保健环境中.
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