粮食不安全和儿科非酒精性脂肪性肝病的严重程度
Sarah Orkin1, Xueheng Zhao2, Kenneth D R Setchell2
1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
儿童非酒精性脂肪性肝病 (NAFLD) 常见的食物不安全性,与早期疾病发病有关. 皮肤脂组学表明潜在的炎症途径.
科学领域:
- 儿科胃肠病学和肝病学
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
背景情况:
- 儿童非酒精性脂肪性肝病 (NAFLD) 是一个日益严重的健康问题.
- 儿童NAFLD中粮食不安全等社会经济因素的作用未得到充分研究.
研究的目的:
- 调查粮食不安全与儿科NAFLD之间的联系.
- 用皮肤脂管学来探索潜在的病理生理机制.
主要方法:
- 这是一项涉及儿科患者 (21岁以下) 经组织学确认的NAFLD的横截面研究.
- 家庭粮食安全调查模块用于评估粮食不安全.
- 在一小部分患者身上进行皮肤脂质检查.
主要成果:
- 儿童NAFLD患者中有42%的人存在粮食不安全.
- 粮食不安全的儿童比粮食安全的儿童早大约2年出现NAFLD.
- 皮肤脂质检测显示,在食物不安全的患者中,氨酸脂质的下调调节可能与炎症有关.
结论:
- 在儿科NAFLD中,粮食不安全非常普遍.
- 粮食不安全与儿科NAFLD的早期呈现年龄有关.
- 脂质学发现表明潜在的病理生理学联系需要进一步调查.
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