使用机器学习方法分析尿路多环芳和美国成年人的慢性肠道疾病之间的关联
Xiaodong Zang1, Liandong Feng2, Wengang Qin3
1Department of Pediatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Chemosphere
|November 6, 2023
概括
对多环芳 (PAH) 的更高暴露与美国成年人慢性腹风险增加有关. 这项研究使用国家卫生数据调查了PAHs和肠道疾病之间的联系.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
背景情况:
- 慢性肠道疾病有复杂的原因,环境因素,如有害物质可能有助于.
- 将多环芳 (PAH) 与慢性肠道疾病联系在一起的研究是有限的.
研究的目的:
- 调查美国成年人接触9种PAH和慢性腹和便秘之间的关系.
- 为了确定与慢性肠道疾病风险增加相关的特定PAHs.
主要方法:
- 利用了2009-2010年的国家健康和营养检查调查 (NHANES) 数据.
- 采用无监督 (集群,PCA) 和监督 (WQS,BKMR回归) 的学习技术.
- 分析了PAH混合物与慢性腹/便秘之间的关联.
主要成果:
- 主要成分分析 (PCA) 确定了三个组成部分,解释了86.5%的PAH变异性;一个组成部分与慢性腹有轻微的关联.
- 克-平均集群显示,更高的PAH暴露集群增加了慢性腹的几率,但不是便秘.
- 重量定量总和 (WQS) 回归表明PAH混合物和慢性腹之间存在积极联系;贝叶斯核机 (BKMR) 分析突出了四种特定的PAH影响慢性腹风险.
结论:
- 对PAHs的更高暴露显然与慢性腹风险增加有关.
- 没有发现PAH暴露和慢性便秘之间有意义的联系.
- 特定的PAH可能在慢性腹的发病过程中发挥重要作用.
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