Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Translational Regulation01:29

Translational Regulation

25
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
25
Types of RNA01:20

Types of RNA

5.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.8K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

920
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
920
Riboswitches01:56

Riboswitches

8.1K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
8.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Impact of Gonadotropin-releasing Hormone Agonist Combined with Lauromacrogol on Ovarian Reserve Function and Pain Scores in Patients with Ovarian Endometriotic Cysts.

Gynecology and minimally invasive therapy·2026
Same author

Engineered Injectable Coaxial Supramolecular Hydrogel for a Minimally Invasive Neural Electrode.

ACS applied bio materials·2026
Same author

Optical alignment method for transmitter-receiver terminals based on camera focusing and transmitter defocus measurement.

Optics express·2026
Same author

Quantitative analysis of posterior chamber morphology on vault after ICL implantation: a retrospective paired study.

International journal of ophthalmology·2026
Same author

Rosmarinic acid-derived micelles potentiated dextran hydrogel for concurrent mechanical reinforcement and inflammatory microenvironment remodeling in chronic diabetic wound healing.

Carbohydrate polymers·2026
Same author

A hollow MnO<sub>2</sub> nanozymes empowered injectable hydrogel for intrauterine adhesion therapy by alleviating oxidative stress and promoting endometrial repair.

Biomaterials science·2026
Same journal

MAGED1 stabilizes NEUROD1 to promote Per3 expression in the pineal gland.

Life sciences·2026
Same journal

TNF-centered network pharmacology and molecular modeling of selected Andrographis paniculata compounds in hypertension.

Life sciences·2026
Same journal

Retraction notice to "Beneficial effect of Calculus Bovis Sativus on 17α-ethynylestradiol-induced cholestasis in the rat" [Life Sci. 113 (2014) 22-30].

Life sciences·2026
Same journal

Soluble PD-1 drives renal fibrosis in CKD by disrupting immune homeostasis: Therapeutic mitigation via a targeted sPD-1 sequestration strategy.

Life sciences·2026
Same journal

METTL1 promotes hepatic steatosis by mediating m<sup>7</sup>G modification of ALOX15B mRNA.

Life sciences·2026
Same journal

SLC30A9-mediated mitochondrial zinc homeostasis drives osteosarcoma chemoresistance by suppressing the mtDNA-cGAS-STING pathway.

Life sciences·2026
查看所有相关文章

相关实验视频

Updated: Jul 11, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.6K

非编码RNAs:多功能调节器的内皮功能障碍.

Xiong Piao1, Lie Ma1, Qinqi Xu1

  • 1Cardiovascular Surgery, Yanbian University Hospital, Yanji 133000, China.

Life sciences
|November 6, 2023
PubMed
概括
此摘要是机器生成的。

非编码RNAs调节动脉样硬化中的内皮功能障碍. 了解这些相互作用为这种慢性炎症疾病提供了新的治疗策略.

关键词:
动脉样硬化是一种动脉样硬化.内皮质功能障碍 内皮质功能障碍没有编码的RNAs.

更多相关视频

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

2.8K
Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers
08:50

Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers

Published on: October 21, 2018

9.1K

相关实验视频

Last Updated: Jul 11, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.6K
Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

2.8K
Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers
08:50

Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers

Published on: October 21, 2018

9.1K

科学领域:

  • 心血管生物学 心血管生物学
  • 分子医学是分子医学.
  • 遗传学 是一个遗传学.

背景情况:

  • 动脉样硬化涉及内皮功能障碍 (ECD),是一种慢性炎症过程.
  • 非编码RNAs (ncRNAs) 是ECD中细胞过程的关键调节者.
  • ECD有助于动脉壁中的斑块形成.

研究的目的:

  • 审查ncRNAs在动脉样硬化期间内皮功能障碍中的调节作用.
  • 突出特定的ncRNA,它们的点和ECD病变发生的机制.
  • 探索ncRNAs与当前动脉样硬化疗法之间的相互作用.

主要方法:

  • 在动脉样硬化和内皮功能障碍中对非编码RNA的文献综述.
  • 对微RNA,长非编码RNA和圆形RNA的分析.
  • 检查治疗点及其ncRNA相互作用.

主要成果:

  • 在ECD中,ncRNAs关键调节炎症,热,迁移,增殖,亡,氧化应激和血管生成.
  • 特定的ncRNA及其与ECD病原发生相关的基因被确定.
  • 讨论了现有的动脉样硬化治疗和ncRNAs之间的相互作用.

结论:

  • ncRNAs是动脉样硬化中内皮功能障碍的多功能调节者.
  • 在ECD中理解ncRNA网络可以导致新的治疗策略.
  • 向ncRNAs为对抗动脉样硬化提供了一个有希望的途径.