高脂肪饮食养破坏了热调节与能量恒温的合
Jennifer D Deem1, David Tingley2, Christina A Watts1
1University of Washington Medicine Diabetes Institute, Department of Medicine, Seattle, WA, USA.
Molecular metabolism
|November 6, 2023
概括
高脂肪饮食 (HFD) 损害了身体在暴露在寒冷中增加能量摄入的能力,导致体重减轻,尽管保持了核心体温. 这种饮食破坏了温度调节和能量平衡系统的整合.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 身体生理学 身体生理学
背景情况:
- 维持核心体温需要适应性热生成和能量摄入.
- 阿古蒂相关 (AgRP) 神经元整合了温度调节和能量恒温.
- 暴露于寒冷会激活AgRP神经元以增加食物摄入量.
研究的目的:
- 调查高脂肪饮食 (HFD) 消费如何影响对寒冷的适应性反应.
- 检查HFD对AgRP神经元对寒冷反应的影响.
主要方法:
- 使用免疫组织化学,体内纤维光度和间接热量计.
- 测量核心温度,能量消耗和能量摄入.
- 在不同的环境温度下比较食和HFD食的小鼠.
主要成果:
- 用HFD养的小鼠保持了核心温度和对寒冷的热能反应.
- 寒冷期间的能量摄入量增加在HFD养的小鼠中减弱,导致体重减轻.
- 在两种饮食中都发生了冷诱导的AgRP神经元激活,但在HFD养的小鼠中,响应神经元的数量减少了.
结论:
- 高晶体养扰乱了温度调节和能量恒温的整合.
- 这种干扰会在暴露在寒冷中损害身体脂肪质量的保护.
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