典型药品的光降解改变了河口水中藻类的毒性:一种代谢学的洞察力
Jiang Lin1, Lianbao Chi2, Qing Yuan3
1College of the Environment & Ecology, Xiamen University, Xiamen 361100, China.
The Science of the total environment
|November 6, 2023
概括
像西普洛素 (CIP) 和狄克洛芬 (DCF) 这样的药物在海洋环境中分解,形成有毒产品. 这些光解产品带来了重大的生态风险,甚至超过了原始药物的毒性.
科学领域:
- 环境化学环境化学
- 海洋生态毒理学 海洋生态毒理学
- 制药科学 制药科学
背景情况:
- 药品在海洋环境中普遍存在,这引发了生态风险的担忧.
- 关于光解等自然过程中产生的药品降解产品的毒性知识有限.
研究的目的:
- 在模拟的河口水中调查 (CIP) 和二 (DCF) 的光降解.
- 识别光降解产品并评估它们对海洋生物的毒性.
主要方法:
- 在模拟的河口水中进行光降解实验.
- 使用高分辨率液体染色学-质谱学识别转化产品.
- 在海洋藻类 (Heterosigma akashiwo) 的毒性预测和非向代谢学.
主要成果:
- CIP和DCF在1小时内完全光解,形成多个转化产品.
- 在分析表明这些产品的持久性,生物积累潜力和多终点毒性.
- 光解DCF混合物诱导了海洋藻类的显著氧化应激和细胞损伤,完全光解显示的毒性比DCF本身更高.
结论:
- 这项研究揭示了制药光解产品在海洋生态系统中显著的,以前被忽视的毒性.
- 主流药品的光解驱动转化产品存在严重的生态风险.
- 关注的是制药天然衰减工艺对环境的影响.
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