使用芳香酶抑制剂的眼部不良事件的风险
Zhao Xun Feng1, Aswen Sriranganathan1, Cody Lo1
1Department of Ophthalmology, University of Ottawa, Ottawa, ON.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
|November 6, 2023
概括
用于乳腺癌治疗的芳香酶抑制剂 (AI) 与眼部不良事件的风险增加有关. 临床医生的警对于接受人工智能治疗的患者的早期检测和干预至关重要.
科学领域:
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
- 药物监督 药物监督 药物监督
背景情况:
- 芳香酶抑制剂 (AIs) 是激素受体阳性乳腺癌的标准辅助治疗方法.
- 新出现的证据表明,人工智能使用与各种眼部不良事件 (AE) 之间存在潜在联系.
研究的目的:
- 在使用芳香酶抑制剂的患者中评估特定眼部AE的风险.
- 确定个人AI和眼部并发症之间的关联.
主要方法:
- 对FDA不良事件报告系统 (2004-2022) 的不成比例分析.
- 搜索眼部的副作用,包括斑点,视网膜沉积和与阿纳斯特,莱特和埃克塞梅斯坦相关的视觉神经病变.
- 使用trastuzumab作为对照,计算了报告的几率比率 (ROR) 和95%的置信区间 (CI).
主要成果:
- 在三个AI中确定了322个眼睛AE.
- 亚纳斯托佐尔与玻璃瘤引力 (ROR=665),黄斑 (ROR=37),视网膜沉积物 (ROR=11) 和脑膜炎 (ROR=6) 有着强烈的关联.
- 莱特醇与视网膜沉积 (ROR=8) 和视网膜动脉封闭 (ROR=6) 相关;埃克塞梅斯坦与黄斑孔 (ROR=10) 相关.
结论:
- 芳酶抑制剂与眼部不良事件的风险增加有关.
- 瘤学家和眼科医生应监测人工智能治疗患者的潜在眼部并发症.
- 及时干预可以减轻使用AI的患者进一步的眼部疾病.
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