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Updated: Jul 11, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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一子,协同减少氨基化/化-环化,用于从基托或氨基酸中合成乳酸

P Veeraraghavan Ramachandran1, Shivani Choudhary1

  • 1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.

The Journal of organic chemistry
|November 6, 2023
PubMed
概括

新的单三酸氧氨酸试剂使得从氨基酸或酸中合成罗利丁-2-和利丁-2-的单合成成为可能. 这种高效的方法简化了制造有价值的异环化合物.

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The pinacol and McMurry reactions involve the reductive coupling of ketones or aldehydes. Similarly, the bimolecular reductive coupling of two ester molecules in the presence of sodium metal in an aprotic solvent yields an α-hydroxy ketone product. The α-hydroxy ketone is also called acyloin, so the reaction is referred to as ‘acyloin condensation.’
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In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
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