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相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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相关实验视频

Updated: Jul 11, 2025

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
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Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

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用于小鼠突变分析的特殊育种技术.

Virginia E Papaioannou1, Richard R Behringer2

  • 1Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA vep1@columbia.edu.

Cold Spring Harbor protocols
|November 6, 2023
PubMed
概括
此摘要是机器生成的。

专门的育种技术有助于分析基因突变及其相互作用. 补充测试和基因相互作用研究有助于了解基因功能和表型.

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Mouse Genome Engineering Using Designer Nucleases
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Mouse Genome Engineering Using Designer Nucleases

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Generation of Genetically Modified Mice through the Microinjection of Oocytes
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Generation of Genetically Modified Mice through the Microinjection of Oocytes

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相关实验视频

Last Updated: Jul 11, 2025

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08:01

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

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Mouse Genome Engineering Using Designer Nucleases
12:04

Mouse Genome Engineering Using Designer Nucleases

Published on: April 2, 2014

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Generation of Genetically Modified Mice through the Microinjection of Oocytes
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Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

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科学领域:

  • 遗传学 是一个遗传学.
  • 分子生物学分子生物学

背景情况:

  • 了解基因突变及其相互作用对于破译生物过程至关重要.
  • 用各种繁殖技术和遗传分析来研究基因功能.

研究的目的:

  • 详细说明用于突变分析的专业育种技术.
  • 解释研究遗传相互作用的方法.

主要方法:

  • 补充测试用于识别等位基因.
  • 繁殖策略,以产生和测试条件和低形态等位基因.
  • 分析基因家族,生化途径和具有相似表型的基因中的遗传相互作用的方法.

主要成果:

  • 专业的育种技术可以揭示基因功能和等位基因关系.
  • 补充测试可以根据相似的表型识别潜在的等位基.
  • 基因相互作用研究阐明了基因之间的功能关系.

结论:

  • 先进的育种和遗传分析是突变特征的重要工具.
  • 了解基因相互作用,可以了解复杂的生物途径和基因冗余.
  • 这些方法促进了对基因功能,调节和进化关系的研究.