早期发病与晚期发病的2型糖尿病中的心血管疾病风险在中国:基于人口的横截面研究
Fei Chen1, Liping Yu1, Shuo Xie2
1Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
Journal of diabetes
|November 6, 2023
概括
早期发病的2型糖尿病 (EOD) 与晚发病的2型糖尿病 (LOD) 相比,显著增加非致命心血管疾病 (CVD) 的风险. 这凸显了为EOD患者量身定制的管理策略的需要,以减轻心血管疾病风险.
科学领域:
- 内分泌学和新陈代谢学
- 心血管疾病流行病学
- 公共卫生 公共卫生
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- T2DM发病的年龄可能会影响患心血管疾病 (CVD) 的风险.
- 研究早期T2DM (EOD) 和晚期T2DM (LOD) 之间的差异对于风险分层至关重要.
研究的目的:
- 为了比较中国早期发病的2型糖尿病 (EOD) 和晚发病的2型糖尿病 (LOD) 患者之间非致命性心血管疾病 (CVD) 的患病率和风险.
- 为了确定与EOD患者心血管疾病相关的风险因素.
- 为不同的T2DM发病群体提供有针对性的预防和管理策略.
主要方法:
- 在中国14个省份,对4949名被诊断患有2型糖尿病的参与者进行了横截面调查.
- 根据诊断时的年龄,参与者被分为EOD (<40岁) 或LOD (≥40岁).
- 使用后勤回归分析来评估EOD/LOD与非致命心血管疾病之间的关联,并根据各种人口,临床和生活方式因素进行调整.
主要成果:
- 非致命性心血管疾病的患病率在EOD组 (11.4%) 与LOD组 (4.4%) 相比显著更高.
- 与LOD患者相比,EOD患者的非致命心血管疾病风险更高 (调整的OR为1.8),即使考虑到糖尿病持续时间和其他风险因素.
- 代谢综合征在EOD患者中进一步增加了心血管疾病风险 (OR 2.0).
结论:
- 早期发病的2型糖尿病是非致命性心血管疾病的独立风险因素.
- EOD患者需要个性化干预和管理计划,以应对他们的心血管疾病风险升高.
- 这些发现强调了早期检测和T2DM积极管理的重要性.
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