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Updated: Jul 11, 2025

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
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在未感染和慢性感染个体中发展HIV-1 bNAb序列特征的概率

Christoph Kreer1, Cosimo Lupo2,3, Meryem S Ercanoglu1

  • 1Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.

Nature communications
|November 6, 2023
PubMed
概括

开发一种HIV-1疫苗至关重要. 这项研究表明,即使没有感染,身体也可以产生强大的HIV-1广泛中和抗体 (bNAbs),为未感染个体的疫苗开发提供希望.

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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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