一个新的路径的levodopa代谢由开始的Bifidobacteria代谢
M S Cirstea1,2, A Creus-Cuadros1,2, C Lo1,2
1Department of Microbiology and Immunology, University of British Columbia (UBC), Vancouver, BC, Canada.
Scientific reports
|November 6, 2023
概括
一些肠道细菌,Bifidobacterium,将莱沃多巴 (L-DOPA) 代谢成3,4-二基酸 (DHPLA). 帕金森病患者的这一发现可能会影响L-DOPA治疗策略.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 利沃多巴 (L-DOPA) 是帕金森病 (PD) 的主要治疗方法,但其疗效受到周围代谢的限制.
- 改变肠道微生物群组成,特别是增加Bifidobacterium丰富性,是PD患者的一致发现.
- 某些Bifidobacterium物种可以代谢L-tyrosine,这是L-DOPA的结构模拟物.
研究的目的:
- 为了研究开始性Bifidobacteria代谢L-DOPA的潜力.
- 为了探索Bifidobacterium丰富度,L-DOPA剂量和PD患者血清氨酸水平之间的关系.
主要方法:
- 对帕金森病患者的临床队列数据的分析.
- 在体外实验中使用特定的Bifidobacterium物种 (B. bifidum,B. breve,B. longum).
- 代谢途径分析以确定L-DOPA转化产物和相关基因.
主要成果:
- 在PD患者中,Bifidobacterium的丰度与L-DOPA剂量呈正相关,与血清氨酸呈负相关.
- 在体外,B. bifidum,B. breve和B. longum通过去胺和减少将L-DOPA代谢为3,4-二基酸 (DHPLA).
- 这种新陈代谢利用现有的氨酸代谢基因,在营养有限的条件下被上调.
结论:
- 交叉双菌具有将L-DOPA代谢成DHPLA的能力.
- 这种新的代谢途径可能会导致PD患者的L-DOPA药理动力学变化.
- 了解这种相互作用可以为未来的帕金森病L-DOPA药物管理策略提供信息.
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