菌体治疗对大西洋鱼 (Salmo salar) 养殖系统中的水中微生物群的影响最小,同时仍能防止感染
Alexander W Fiedler1, Madeleine S Gundersen1, Toan P Vo1
1Department of Biotechnology and Food Science, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Scientific reports
|November 6, 2023
概括
菌体治疗为保护大西洋鱼幼鱼免受Flavobacterium columnare感染提供了抗生素的有希望的替代品. 这项研究表明,菌体治疗可以提高鱼类的生存率,而不会破坏关键的水生微生物群.
科学领域:
- 水生微生物学 水生微生物学
- 动物健康 动物健康
- 菌体的研究研究研究.
背景情况:
- 过度使用抗生素会对动物微生物群多样性产生负面影响.
- 菌体治疗正在被探索作为一种节省微生物群的替代方案.
- 杆菌 (Flavobacterium columnare) 对年轻鱼类构成重大威胁.
研究的目的:
- 评估菌体治疗作为抗生素的替代品,用于控制大西洋鱼中的Flavobacterium columnare.
- 评估菌体治疗对鱼类存活率和水生细菌群落对氧化环素的影响.
- 调查大西洋鱼黄囊幼中微生物群对F. columnare.的保护作用.
主要方法:
- 挑战试验与无细菌和微生物殖民的大西洋鱼黄囊.
- 细菌治疗和氧基环素的应用.
- 对鱼类生存率的分析.
- 16S rRNA基因扩增序列测序以表征养殖水中的细菌群体.
主要成果:
- 菌体治疗显著增加了F. columnare挑战鱼的生存率.
- 菌体处理减少了F. columnare在养殖水中的丰富性,而不会改变微生物群的多样性.
- 对鱼类的生存或水中的微生物群没有显著影响.
- 微生物群的存在保护了鱼幼免受致命的F. columnare感染.
结论:
- 菌体治疗是一种有效的,节省微生物群的替代抗生素,用于管理水产养殖中的F. columnare感染.
- 微生物群在保护幼鱼免受细菌病原体的侵害方面发挥着至关重要的作用.
- 菌体治疗是一种可行的策略,可以在不损害水生生态系统平衡的情况下改善鱼类的健康.
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