转硫化途径在缺乏维生素D的小鼠精子生成中的作用
Narges Jamshidian-Ghalehsefidi1,2, Farzaneh Rabiee3, Marziyeh Tavalaee4,5
1ACECR Institute of Higher Education, Isfahan Branch, Isfahan, Iran.
Scientific reports
|November 6, 2023
概括
维生素D缺乏会通过降低精子质量和水平,损害男性生育能力. 这项研究表明,这种效应与转硫途径有关,而不仅仅是维生素D受体.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 营养科学 营养科学
背景情况:
- 维生素D缺乏是与男性不孕症相关的普遍问题.
- 缺陷的精子生成是维生素D缺乏的一个已知的后果.
研究的目的:
- 为了研究维生素D缺乏对转硫途径中的酶的影响.
- 检查小鼠中维生素D缺乏,精子生成和1碳代谢之间的关系.
主要方法:
- 雄性C57小鼠被食标准或缺乏维生素D (VDD) 的饮食14周.
- 在转硫途径中的关键酶 (CBS,CSE,HO-1) 在mRNA和蛋白质水平上进行了分析.
- 测量了精子质量,水平,同型半素,维生素B12和氧化应激标志物.
主要成果:
- 维生素D缺乏会降低精子质量,丸结构和水平.
- 在缺乏这种蛋白质的小鼠中,同类氨酸,维生素B12和精子氧化压力标志物增加.
- 在CBS和CSE蛋白水平下降,而在丸组织中HO-1增加.
结论:
- 维生素D缺乏会通过氧化应激机制损害男性的生殖功能和精子生成.
- 观察到的效应似乎独立于基因组维生素D的作用,这表明转硫化途径的作用.
- 这突显了维生素D缺乏引起的不孕症中另一种转硫化途径的特定损害.
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