在休息时的清醒状态和睡眠时的间接侵袭性非常高频振荡
Karin Revajová1, Vojtěch Trávníček2,3, Pavel Jurák2
1Brno Epilepsy Center, Department of Neurology, member of ERN-EpiCARE, St Anne's University Hospital and Medical Faculty of Masaryk University, Brno, 602 00, Czech Republic. karin.revajova@fnusa.cz.
Scientific reports
|November 6, 2023
概括
休息期间的非常高频振荡 (VHFO) 预测了成功的手术结果. 虽然VHFO在睡眠期间更常见,但与静止状态分析相比,它们并没有进一步改善手术结果.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 临床电生理学 临床电生理学
背景情况:
- 传统的间接高频振荡 (HFO,80-500 Hz) 被用来预测手术的结果.
- 我们团队之前的一项研究表明,静止状态下的间接非常高频振荡 (VHFO,500-2000 Hz) 是良好的外科手术结果的更具体的预测因素.
- 睡眠期间VHFO的发生尚未被广泛研究,与外科手术结果相关.
研究的目的:
- 与传统的HFO相比,重新测试休息状态的VHFO是良好的手术结果的更具体预测因素的假设.
- 调查睡眠期间VHFO的发生情况,并将其与休息状态进行比较.
- 为了确定睡眠期间的VHFO是否可以进一步改善外科手术结果的预测.
主要方法:
- 在休息状态下记录了104名耐药性患者的间脉冲性侵入性脑电图 (iEEG) 振荡.
- 在35名患者的睡眠过程中记录了EEG振荡.
- 分析了来自满足包括标准 (存在HFO和VHFO,手术干预和≥1年的随访) 的患者的iEEG数据,无论是休息状态还是睡眠状态.
主要成果:
- 在休息状态下,具有良好的术后结果的患者显示,与VHFO相比,与HFO相比,切除VHFO的接触者比例显著更高.
- 在睡眠期间,VHFO比在休息状态时更为丰富.
- 切除接触者的百分比在睡眠期间任何振荡类型的良好和不良结果的患者之间没有显著差异.
结论:
- 结果证实,VHFO是需要切除的发性区域的特定预测因素,支持较大的队列中先前的发现.
- 与休息状态记录相比,睡眠期间VHFO的增加不会为手术结果提供额外的预测价值.
- 静止状态的VHFO仍然是指导药物耐药性的手术干预的宝贵生物标志物.
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