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在灵长类动物的轨道前皮层中,从种群值信号的行为读出

Vincent B McGinty¹, Shira M Lupkin^2,3

¹Center for Molecular and Behavioral Neuroscience, Rutgers University-Newark, Newark, NJ, USA. vince.mcginty@rutgers.edu.

Nature neuroscience

|November 6, 2023

概括

灵长类动物选择的变化是由来自轨道前皮层 (OFC) 神经元的价值信号解释的. 这揭示了OFC神经活动如何转化为经济决策,这表明了人口层面的读出机制.

科学领域:

神经科学是一个神经科学.
决策神经科学决策神经科学
灵长类神经生理学

背景情况:

灵长类动物的轨道前皮层 (OFC) 参与了基于价值的决策.
连接OFC值表示与行为选择的精确神经机制仍然不清楚.

研究的目的:

阐明轨道前皮层 (OFC) 影响经济决策的神经机制.
将选择的试验智能变化与OFC内的神经活动模式联系起来.

主要方法:

在非人类灵长类动物中,从多个轨道前皮层 (OFC) 神经元同时记录神经活动.
从OFC神经群活动中解码价值信号.
在逐个试验的基础上,分析解码的价值信号和行为选择之间的关系.

主要成果:

试验对试验的选择变化在很大程度上是由OFC神经群体解码的值信号变化解释的.
观察到的神经-行为关系与OFC活动从低维的值编码子空间投射到行为相关的输出子空间的模型保持一致.
这提供了OFC价值表示和决策结果之间的机制联系.

结论:

这项研究确定了轨道前皮层 (OFC) 中一个关键的神经行为联系,用于经济决策.
研究结果表明,OFC采用类似于感觉和运动皮层的种群级读出机制.
这项工作解决了关于OFC在经济选择中的作用的长期问题.

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