纳米图的外部验证,包括MRI特征,用于预测侧面特定的前列腺外延伸
J G Heetman1, E J R J van der Hoeven2, P Rajwa3
1Department of Urology, St. Antonius Hospital, Utrecht, The Netherlands.
Prostate cancer and prostatic diseases
|November 6, 2023
概括
准确预测侧面特异性前列腺外延伸 (EPE) 对于节约神经的激进前列腺切除术至关重要. 纳兰吉-迪克斯,马蒂尼和索特里克名图显示出前列腺癌管理中临床决策的前景.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 准确预测侧面特异性前列腺外延伸 (EPE) 对于选择神经节约激进前列腺切除术 (RP) 患者至关重要.
- 现有的包含磁共振成像 (MRI) 数据的诺姆图需要对临床实用性进行外部验证.
- 确保这些预测工具的可靠性有助于做出明智的医学决策.
研究的目的:
- 在前列腺癌患者中外部验证四种已建立的诺姆图来预测侧面特定的EPE.
- 评估这些名ograms的歧视,校准和净收益.
- 为了确定对EPE预测最有影响力的MRI特征.
主要方法:
- 从773名前列腺癌患者进行机器人辅助激进前列腺切除术 (RARP) 的追溯数据收集在四个欧洲中心 (2017-2021年).
- 外部验证四个先前存在的nomograms为侧面特定的EPE预测.
- 通过曲线下的面积 (AUC),校准图表和净收益分析来评估名ogram性能.
- 多变量回归和Akaike信息标准 (AIC) 用于评估MRI特征预测器.
主要成果:
- 该研究包括773名患者和1546名前列腺叶,EPE检测到22%的叶片.
- 对于EPE预测的诺莫格拉姆AUC在72.2% (维伯) 到75.5% (尼拉兰吉-迪克斯) 之间.
- 尼亚朗吉-迪克斯名图显示,在20-30%之间的风险值中,净益处优越.
- 欧洲泌尿器官放射学学会得分和瘤囊接触长度被确定为最强的MRI预测因素.
结论:
- 尼亚朗吉-迪克斯,马蒂尼和索特里克的诺米图提供了对EPE的准确预测.
- 这些经过验证的诺姆图适用于支持前列腺癌管理中的临床决策.
- 这些发现支持使用这些名图来指导急性前列腺切除术的手术规划.
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