免疫-炎症反应系统 (IRS) /补偿性免疫调节反射系统 (CIRS) 与精神分裂症第一发病患者的白质完整性的相关性
Mengzhuang Gou1, Wei Li1, Jinghui Tong1
1Beijing Huilongguan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, China.
Molecular neurobiology
|November 6, 2023
概括
免疫-炎症反应系统/补偿性免疫调节反射系统 (IRS/CIRS) 的升高与第一发精神分裂症中白质完整性降低有关. 这种免疫失衡特别影响皮质脊髓,这表明精神分裂症的作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症与损害白质完整性和功能性大脑失联性有关.
- 免疫失衡,特别是免疫-炎症反应系统和补偿性免疫调节反射系统 (IRS/CIRS),与精神分裂症的病理生理学有关.
- 在精神分裂症中,IRS/CIRS,外围细胞因子和白质微观结构之间的关系仍未得到充分研究.
研究的目的:
- 在第一发精神分裂症患者 (FEPS) 中调查外周细胞因子和IRS/CIRS的复合得分.
- 检查IRS/CIRS与整体白质完整性之间的相关性.
- 在FEPS中识别受IRS/CIRS影响的特定白质微结构.
主要方法:
- 招募了94名FEPS和50名健康对照 (HC).
- 通过ELISA测量了血细胞因子水平,并使用正负综合征量表 (PANSS) 评估了精神病理学.
- 在3T核磁共振扫描仪上通过扩散张力成像 (DTI) 来评估全脑白质完整性.
主要成果:
- 与HC相比,FEPS的IRS/CIRS表现显著更高 (p=1.5×10−5,d=0.74).
- 经过调整后,FEPS显示全脑白质平均FA显著较低 (p=0.032),与IRS/CIRS负相关 (p=0.029).
- 在FEPS中,皮质脊髓系是唯一与IRS/CIRS显著相关的微观结构 (r=-0.543,p=0.0009).
结论:
- 升高的IRS/CIRS是FEPS免疫失调的潜在生物标志物.
- 在FEPS中,IRS/CIRS与白质完整性有负面关联.
- 通过IRS/CIRS表示的免疫失衡,在精神分裂症中可能会特别影响皮质脊髓.
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