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耳癌中的免疫检查点分析

M Klein¹, E Polgart², C Hallermann^3,4

¹Department of Oral & Maxillofacial Surgery, School of Medicine, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. mauklein@ukaachen.de.

Head & face medicine

|November 7, 2023

概括

评估了耳部状细胞癌 (ecSCC) 的预后标志物. 虽然CD8和FoxP3与疾病特异性死亡有一定的相关性,但测试的标记物通常不适合预测ecSCC的结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病理学皮肤病理学

背景情况:

耳部皮肤状细胞癌 (ecSCC) 是一种常见的癌症.
局部淋巴结转移发生在6-11%的ecSCC病例中.
需要用于ecSCC预后的预测标记.

研究的目的:

评估PD-L1,PD-1,CD4,CD8和FoxP3作为ecSCC的预后标志物.
为了将标记物表达与临床病理学参数相关联.

主要方法:

在64名ecSCC患者中,对PD-L1,PD-1,CD4,CD8和FOXP3表达的免疫组织化学分析.
与临床病理学参数的相关性,包括转移和疾病进展.

主要成果:

弱的FoxP3表达 (p=0.003) 和减少的CD8表达 (p=0.04) 与增加的疾病特异性死亡相关.
在39.1%的患者中观察到PD-L1表达>1%.

结论:

标记物CD4,CD8,FoxP3,PD-1和PD-L1在很大程度上不适合在ecSCC中进行预后评估.
在更大的队列中对CD8和FoxP3进行进一步的研究是有必要的,以获得预后潜力.

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Tumor Immunotherapy

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