地中海协会-DASH干预神经退行性延迟饮食与大脑结构标志物及其变化
Hui Chen1, Michelle M Dunk2, Binghan Wang1
1School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|November 7, 2023
概括
地中海-DASH干预神经退行性延迟 (MIND) 饮食与特定区域的大脑体积增加和白质超强度减少有关. 然而,它没有显示出对英国成年人大脑结构变化的长期显著影响.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 放射学 放射学是一门学科.
背景情况:
- 地中海-DASH干预神经退行性延迟 (MIND) 饮食结合了地中海和DASH饮食的各个方面.
- 它对大脑结构和神经退行症的影响尚未完全理解.
- 了解饮食对大脑健康的作用对于预防认知衰退至关重要.
研究的目的:
- 调查坚持MIND饮食和大脑结构标记之间的关联.
- 为了检查MIND饮食与大脑结构的纵向变化之间的关系.
- 探索这些关联因遗传因素的潜在修改,特别是APOE ε4.4.
主要方法:
- 利用了来自26466名英国生物库参与者的数据 (2009-2012).
- 根据24小时的饮食回忆计算了15分的MIND得分.
- 评估了与17个MRI衍生的大脑体积标记和纵向变化的关联,分析了遗传相互作用.
主要成果:
- 较高的MIND饮食坚持与大脑垂体,肌,皮体,海马体和腹体中较大的体积相关.
- 增加MIND坚持与较低的白质超强度有关.
- 在2.2年内,与纵向大脑结构变化没有发现显著的关联,除了在APOE ε4非载体中缓慢的肌和肌缩.
结论:
- 在英国成年人中,MIND饮食与特定的大脑结构标记有积极的关联.
- 饮食对长期大脑结构变化的影响需要进一步调查.
- 像APOE ε4这样的遗传因素似乎没有改变观察到的与大脑体积的关联.
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