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血管风险,步态,行为和血指标的VCID
Sheelakumari Raghavan1, Scott A Przybelski2, Timothy G Lesnick2
1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
非成像指标可以预测血管对认知障碍和痴呆症 (VCID) 的血管贡献中的白质损伤. 它们的预测值因年龄而异,血管风险和步态对于早期变化很重要,而血标志物对晚期变化很重要.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年学是指老年学的学科.
背景情况:
- 血管对认知障碍和痴呆 (VCID) 的贡献构成了重大的公共卫生挑战.
- 对VCID的成本有效的查工具对于早期检测和干预至关重要.
- 磁共振成像 (MRI) 是评估VCID中白质 (WM) 损伤的关键工具.
研究的目的:
- 评估非成像指标,以预测MRI测量VCID中的白质 (WM) 损伤.
- 为了确定非成像指标与WM损伤之间的关联是否在不同年龄组之间存在差异.
主要方法:
- 利用了745名参与者 (≥50岁) 在梅奥诊所老龄化研究中的数据.
- 评估了使用扩散MRI和FLAIR-MRI的连续WM损伤.
- 检查了基线非成像指标 (人口统计,血管风险因素[VRFs],步态,行为,血GFAP,血NfL) 和WM损伤之间的关联.
主要成果:
- 血管风险因素 (VRF) 和步态与所有年龄组的扩散MRI测量WM变化有关.
- 血质纤维酸蛋白 (GFAP) 和血神经纤维光链 (NfL) 与白质超强度 (WMHs) 相关,主要在中年和老年人群中.
- 大多数非成像指标解释了中年和老年年龄组的WMH变异性.
结论:
- 非成像指标在VCID中有效预测MRI评估的WM损伤.
- 这些指标的预测效用取决于年龄.
- 提出了一个评估新型非成像VCID指标的框架.
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