在中年和老年人中发生远程甲状腺瘤转移的危险因素
1Ya'an Hospital of Traditional Chinese Medicine, Ya'an, China.
Medicine
|November 7, 2023
概括
这项研究开发了一种名谱,用于预测中年和老年肌肉肉瘤患者的远程转移 (DM). 确定的主要风险因素包括婚姻状况,瘤等级和晚期阶段,有助于早期诊断和改善预后.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
- 癌症流行病学 癌症流行病学
背景情况:
- 冠状肉瘤是一种常见的原发性骨癌,特别是在老年人中.
- 远程转移 (DM) 显著恶化了冠状动脉瘤患者的预后.
- 准确预测DM对于中年和老年患者的及时干预至关重要.
研究的目的:
- 开发和验证中年和老年冠状腺癌患者远程转移 (DM) 的预测性名谱.
- 在这个患者队列中确定与DM相关的独立风险因素.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库 (2004-2015) 的数据进行培训和内部验证.
- 从中国一家三级医院 (2012-2021) 收集的外部验证数据.
- 采用后勤回归,接收器操作特征 (ROC) 曲线,校准曲线和决策曲线分析.
主要成果:
- 鉴定了婚姻状况,非分化冠状腺瘤组织学,高瘤等级,T3阶段和N1阶段作为DM的独立风险因素.
- 诺米图表显示出强大的预测准确性,AUC值为0.857 (训练),0.820 (内部验证) 和0.859 (外部验证).
- 校准和决策曲线分析证实了名图在预测DM方面的可靠性.
结论:
- 开发的诺米图准确地预测了中年和老年冠状腺癌患者的远程转移.
- 临床医生应考虑风险分层的确定的风险因素 (婚姻状况,组织学,年级,T3/N1阶段).
- 这种工具可以帮助早期诊断和个性化治疗策略,为chondrosarcoma.
相关概念视频
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
01:30Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
01:19Psychoneuroimmunology: Diabetes and Cancer
31
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
31
01:26Aging
59
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
59