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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

在CD10表达和phyllodes瘤之间的关联:一个回顾性病例控制研究研究.

Fang Tian¹, Jie Zhao¹, Qing-Fang Shi¹

¹Pathology Department, Gansu Provincial Maternity and Child-care Hospital, Lan Zhou, China.

|November 7, 2023

概括

这项研究发现,CD10表达,以及组织学特征,可以帮助区分瘤 (PT) 和纤维腺瘤 (FA). CD10可以作为一个有价值的标志物来区分这些乳腺病变.

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Last Updated: Jul 11, 2025

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科学领域:

在瘤学瘤学.
病理学病理学病理学
生物标志物生物标志物

背景情况:

乳腺瘤 (PT) 和纤维腺瘤 (FA) 是常见的乳腺瘤,具有重叠的组织学特征.
准确的区分对于适当的患者管理和治疗至关重要.
免疫组织化学标志物可能有助于区分PT和FA.

研究的目的:

调查免疫组织化学标志物与植物瘤 (PT) 之间的关联.
分析不同等级PT和FA之间的标记物表达的差异.
为了确定区分PT和FA的潜在标记.

主要方法:

从2014年10月到2021年5月,对69名患者 (34名PT,35名FA) 进行了回顾性病例控制研究.
对CD10,CD117,CD34,P53和Ki-67的组织病理特征和表达的分析.
多变量分析以确定与PT的独立关联.

主要成果:

在PT中恶性瘤的增加与定义不清的边界,异质肌层和肌层细胞性/过度生长的增加相关 (P < .05).
CD10表达独立地与PT相关 (OR = 0.67,P < .05).
组织学特征和CD10表达在PT和FA等级之间存在显著差异.

结论:

组织学特征对于区分PT和FA很重要.
CD10表达独立地与PT相关.
CD10显示出作为phyllodes瘤的分化标记物的潜力.