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微球体脉冲注射的冲效应及其在血液静止下对外围静脉的潜在影响
Jin Li1,2, Yan Wang1, Jian-Xiong Ma1
1Tianjin Hospital, Tianjin University, Tianjin, People's Republic of China.
Medicine
|November 7, 2023
概括
微球体脉冲注射有效减少高度注射的稀释,对成像剂有好处. 这种方法减少了注射体积和速度,最大限度地减少了静脉冲击.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 医疗成像医学成像
背景情况:
- 高度注射在管道中的稀释可能会影响成像剂的疗效.
- 低液体体积玻尿酸注射需要了解低注射速度的影响.
- 输液成像应用,如放射性药物动态成像,通常需要小体积,高度的注射.
研究的目的:
- 评估微球体脉冲注射用于减少管道稀释的可行性.
- 为了研究低液体体积玻尿酸注射在低速度的动态.
- 为了比较脉冲对血管的影响与直接注射方法.
主要方法:
- 使用可编程脉冲注射通过管道冲洗光剂.
- 通过测量完全消失光剂的时间来记录冲洗效率.
- 运用计算流体动力学 (CFD) 来模拟两相流的有限元模拟,比较切割速率和压力分布.
主要成果:
- 微球体脉冲注射使有效冲洗量减少了49.7%,平均注射速度减少了56%.
- 与非脉冲注射相比,这种方法保持了较短的高切割率和较短的持续时间.
- 随着血液静止距离的增加 (100毫米),微球脉冲注射对静脉产生了相似或较低的负面影响.
结论:
- 微球脉冲注射是有效的克服成像剂在管道中的稀释,特别是高度,小体积的应用.
- 该技术在 perfusion 成像方面具有优势,减少了对大量注射量的需求.
- 仔细控制血液静止距离至关重要,以减轻对外围静脉的潜在不良影响.
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