使用新的表面修饰和生物伪装介导技术来逃避宏分子的opsonization,用于下一代药物输送
1Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM'S Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-be-University, Mumbai, India.
Cell biochemistry and function
|November 7, 2023
概括
异能化阻碍了纳米粒子药物输送. 像PEGylation和生物伪装这样的表面修饰提供了隐形特性,使下一代纳米平台的循环时间更长,治疗效率更好.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 奥普森化导致巨细胞破坏纳米粒子,限制药物输送系统.
- 第一代和第二代纳米配方由于免疫系统的吸收而面临限制的疗效.
- 网状尾细胞系统和单核细胞系统的相互作用阻碍了药物可控释放.
研究的目的:
- 审查表面修饰技术,以克服纳米配方中的opsonization.
- 探索诱导纳米粒子隐形性质和免疫逃脱的方法.
- 为突出长循环纳米平台的开发,以加强治疗.
主要方法:
- 使用宏分子介导方法 (PEGylation,区块共聚合) 的表面修饰.
- 使用生物方法,如细胞车和失声蛋白质吸附.
- 研究免疫规避的硬体力量和生物伪装.
主要成果:
- 巨分子介导技术赋予隐形性质,驱逐opsonin和减轻opsonization.
- 生物伪装策略通过将蛋白质吸附到纳米粒子表面来促进免疫逃生.
- 开发的技术为具有卓越治疗潜力的长循环纳米平台铺平了道路.
结论:
- 表面修饰对于克服纳米粒子药物输送中的opsonization至关重要.
- 先进的技术使纳米粒子能够逃避免疫检测,改善治疗结果.
- 未来与人工智能的集成可以预测纳米粒子-免疫系统相互作用,以优化纳米平台设计.
相关概念视频
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