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Updated: Jul 11, 2025

Development of a Human Preclinical Model of Osteoclastogenesis from Peripheral Blood Monocytes Co-cultured with Breast Cancer Cell Lines
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瘤诱导的骨质疏松症:一个病例报告和病因分析与文献综述

Zhenhao Zhang1, Jiaxin Li1, Zhicai Zhang1

  • 1Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Orthopaedic surgery
|November 7, 2023
PubMed
概括

瘤诱导性骨质疏松症 (TIO) 是一种罕见的副瘤综合征,通常是由酸盐尿层介质瘤 (PMT) 引起的. 手术切除瘤分泌纤维细胞生长因子23 (FGF23) 有效地缓解了症状,并使骨代谢标志物正常化.

关键词:
病理起因 病理起因 病理起因文献综述 文献综述 文献综述酸尿中介细胞瘤治疗方法 治疗方法瘤诱导的骨质疏松症

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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