维生素K在重症儿童的凝血病的使用
Christina J Smith1, Ryan Valencia2, Caroline M Sierra3
1Department of Pharmacy, Loma Linda University Children's Hospital, Loma Linda, CA, USA.
Hospital practice (1995)
|November 7, 2023
概括
维生素K有效地治疗重症儿童的凝血病,显示出前列血时间 (PT) 和国际正常化比率 (INR) 的显著改善. 这种治疗是安全的,尽管没有发现剂量反应关系.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科重症监护室 (ICU) 患者的凝血病与较高的死亡率有关.
- 维生素K的管理是维生素K缺乏凝血病的标准治疗方法.
- 在重症儿童中评估维生素K的有效性和安全性至关重要.
研究的目的:
- 评估维生素K在治疗重症儿童凝血病的有效性.
- 确定维生素K剂量与前列血栓时间 (PT) 和国际正常化比率 (INR) 的变化之间是否存在关系.
主要方法:
- 从2013年至2021年,对儿童ICU中年龄≤17岁的患者进行了回顾性队列研究.
- 排除接受维生素K抗剂的患者.
- 分析了PT/INR的变化以及维生素K给药后过敏/过敏反应的发生率.
主要成果:
- 310名患者接受了维生素K,平均每剂量为0.14毫克/千克的3剂量.
- 维生素K第一个剂量后,平均PT/INR显著下降 (p < 0.001).
- 维生素K剂量与PT/INR变化之间没有观察到线性关系;没有报告不良事件,但死亡率为27%.
结论:
- 维生素K是一种有效和安全的治疗维生素K缺乏凝血病在重症儿科患者.
- 需要进一步的研究来确定维生素K和PT/INR之间的剂量反应关系.
- 尽管治疗有效,但高死亡率强调了这一群体中严重疾病的严重程度.
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