使用SOFTGRAM的系统性硬化症患者皮肤硬度的定量评估的探索性研究
Hiraku Kokubu1, Yasuaki Ikuno2, Kazuyuki Uchiyama2
1Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga, Japan. kokubu@belle.shiga-med.ac.jp.
Clinical and experimental rheumatology
|November 7, 2023
概括
一种测量弹性模量的设备SOFTGRAM显示出对系统性硬化症 (SSc) 中客观评估皮肤硬度的前景. 虽然实用,但需要进一步的研究来完善其临床使用的准确性和可靠性.
科学领域:
- 生物医学工程 生物医学工程
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
背景情况:
- 缺乏对皮肤硬度的客观测量.
- 系统性硬化症 (SSc) 的特征是皮肤变厚和硬化.
- 目前用于SSc皮肤参与的评估方法是主观的.
研究的目的:
- 评估 SOFTGRAM 的可行性,这是一种利用赫兹弹性接触理论的设备,用于量化皮肤硬度.
- 评估SOFTGRAM测量的弹性模量与SSc患者的临床皮肤得分之间的相关性.
主要方法:
- 在20名SSc患者和20名对照人群中,SOFTGRAM测量了8个身体部位的皮肤弹性模量.
- 修改的罗丹纳总皮肤厚度得分用于临床评估.
- 两种方法的观察者间和观察者内部可靠性均被评估.
主要成果:
- 在弹性模量和皮肤得分之间发现了显著的正相关性 (r=0.67,p<0.001).
- 在健康对照组,有限的皮肤SSc组和扩散的皮肤SSc组 (p<0.001) 中,弹性模量显著不同.
- 足够的观察者内部可靠性得到了实现,但观察者之间的可靠性需要改进.
结论:
- 软图显示了在SSc.中测量皮肤硬度的实用性和准确性.
- 需要进一步的研究来优化测量技术并提高观察者之间的可靠性.
- 该设备为SSc皮肤评估提供了一个潜在的客观工具.
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