制药剂作为早期结肠直肠癌发展的潜在驱动因素:病例对照研究
Irit Ben-Aharon1, Ran Rotem2, Cheli Melzer-Cohen3
1Department of Gastroenterology, Rambam Healthcare Campus, Haifa, Israel.
JMIR public health and surveillance
|November 7, 2023
概括
早期结直肠癌 (EOCRC) 在年轻人中正在增加. 这项研究表明,某些药物,包括β抑制剂和草,可能与EOCRC风险有关,需要进一步调查.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 自20世纪90年代中期以来,早期结直肠癌 (EOCRC) 发病率急剧上升,特别是在50岁以下的人群中.
- 虽然生活方式因素有关,但突然增加表明可能涉及一个新的风险因素.
- 制药剂被假设是基因敏感的年轻人中EOCRC的潜在驱动因素.
研究的目的:
- 调查药剂使用与患早期结直肠癌 (EOCRC) 的风险之间的关联.
主要方法:
- 通过使用麦卡比医疗保健服务的电子病历进行了一项病例控制研究,其中包括941名EOCRC患者和9410名对照.
- 机器学习算法分析了药物发行数据,以确定与EOCRC相关的药物类别,不包括炎症性肠病或已知的癌症综合征患者.
- 条件后勤回归被用来计算特定药物类别的赔率比率.
主要成果:
- 几种药物类别始终与EOCRC风险相关,特别是β抑制剂和菜 (Valeriana officinalis).
- 在抗生素使用和EOCRC风险之间没有发现一致的关联.
- 在分析中,药物相互作用没有显著改变EOCRC风险.
结论:
- 以前使用特定药物,如β抑制剂和草,可能与早期结直肠癌的发展相关.
- 需要进一步的研究来验证这些发现,并阐明潜在的机制.
- 如果药物剂被证实是EOCRC驱动因素,可以考虑监管风险减轻策略.
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