细胞结构植入物的过程-结构-生物功能范式:增材制造,生物机械行为和生物功能之间的协同作用的概述和视角
1Department of Metallurgical, Materials and Biomedical Engineering and Biomedical and Biomaterials Research Laboratory, Center for Structural and Functional Materials, University of Texas at El Paso, El Paso, Texas, USA.
Artificial cells, nanomedicine, and biotechnology
|November 7, 2023
概括
增材制造使得创建患者特定的植入物能够最大限度地减少应力屏蔽,并满足生物力学要求. 这项技术整合了生物科学和细胞结构,以改善植入物功能.
科学领域:
- 生物材料工程 生物材料工程
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 传统的生物医疗设备制造方法 (造,机械成型) 由于与宿主组织的属性不匹配而存在局限性.
- 增材制造 (AM) 提供了一个解决方案,使得能够创建具有量身定制属性的患者特异性植入物.
研究的目的:
- 探索生物科学和通过AM制造的细胞结构之间的协同作用,用于植入物开发.
- 突出细胞结构植入物的重要性,以解决应力屏蔽和满足生物力学要求.
主要方法:
- 使用增材制造技术,如电子束融和激光粉床融合.
- 利用计算机断层扫描 (CT) 扫描进行患者特定的植入物设计.
- 分析细胞结构,多孔性和机械性质之间的关系.
主要成果:
- 由AM制造的细胞结构植入物可以有效地减少应力屏蔽.
- 通过建筑设计,AM可以精确控制机械性能 (弹性模量,抗冲击,疲劳强度).
- 对这些细胞结构的生物反应是植入成功的关键考虑因素.
结论:
- 增生医学,计算机辅助设计 (CAD) 和结构-属性关系的融合为当前的生物医学挑战提供了解决方案.
- 通过AM制造的细胞结构植入物显示出与传统制造的设备相比,增强集成和性能的潜力.
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