2023年DescribePROT:更多,更高质量的和实验性的注释以及改进的数据下载选项
Sushmita Basu1, Bi Zhao2, Bálint Biró1,3
1Department of Computer Science, Virginia Commonwealth University, Richmond, VA, USA.
Nucleic acids research
|November 7, 2023
概括
扩展的DescribePROT数据库现在提供了增强的蛋白质结构和功能数据,包括实验信息,并改善了各种生物研究的可访问性. 本资源有助于理解蛋白质的作用和疾病机制.
科学领域:
- 结构生物学 结构生物学
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 描述PROT数据库提供了蛋白质结构和功能的氨基酸级描述器.
- 之前的版本在范围和数据类型方面受到限制.
研究的目的:
- 报告DescribePROT数据库的大幅扩展和升级.
- 增强DescribePROT的实用性,用于蛋白质科学和疾病机制研究.
主要方法:
- 综合实验结构数据与预测描述符一起.
- 通过使用11种预测工具,扩大了对273个参考蛋白质的覆盖范围.
- 改进了数据下载选项和升级的图形用户界面.
主要成果:
- 描述PROT现在包括19个结构和功能描述符.
- 数据库提供了增强的数据大小,范围和质量.
- 新功能促进了多功能数据搜索,交互和下载.
结论:
- 更新的DescribePROT数据库是蛋白质结构功能研究的宝贵资源.
- 它的全面注释支持疾病机制和治疗开发的研究.
- 免费访问的资源是为了更广泛的科学应用而增强的.
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