人类衰老基因组资源:对衰老研究中关键数据库的更新
João Pedro de Magalhães1, Zoya Abidi2, Gabriel Arantes Dos Santos1
1Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2WB, UK.
Nucleic acids research
|November 7, 2023
概括
人类衰老基因组资源 (HAGR) 为研究老龄化和寿命的研究人员提供了一个全面的,专家策划的数据库和工具集合. 这些更新的资源促进了对影响衰老过程的基因,药物和遗传变异的探索.
科学领域:
- 基因组学就是基因组学.
- 衰老研究研究 衰老研究
- 生物信息学是一种生物信息学.
背景情况:
- 衰老是一个复杂的生物过程,受到许多因素的影响.
- 20年来,人类衰老基因组资源 (HAGR) 已成为衰老研究的宝贵工具.
- 持续更新和专家策划对于保持准确和相关的老化研究数据库至关重要.
研究的目的:
- 介绍人类衰老基因组资源 (HAGR) 的关键特征和最近的改进.
- 突出HAGR六个综合数据库对研究衰老,寿命和相关干预措施的有用性.
- 为研究人员提供有关与衰老相关的基因,药物和遗传变异的最新,精选的数据.
主要方法:
- 从科学文献中收集和整理数据.
- 整合了六个专门的数据库:GenAge,AnAge,DrugAge,GenDR,CellAge和长寿地图.
- 开发与衰老过程相关的基因表达特征的工具和元分析.
主要成果:
- 在HAGR中包括GenAge (307个人类衰老基因,2205个模型生物基因),AnAge (4645个物种),DrugAge (1097个化合物),GenDR (214个基因),CellAge (866个基因) 和LongevityMap (3144个变异).
- 数据库是集成的,定期更新,并由专家手动策划.
- 哈格提供工具和基因表达标志的基因表达标志的元分析,老化,饮食限制,和衰老.
结论:
- HAGR为科学界提供了一个强大的,免费可访问的在线资源.
- 综合和精心策划的数据库有助于研究衰老的遗传和分子基础.
- 持续的更新确保HAGR仍然是推动了解和操纵衰老的重要平台.
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