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相关概念视频

Protein Families02:47

Protein Families

15.4K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
15.4K
Protein Folding01:25

Protein Folding

8.1K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
8.1K
Protein Organization01:24

Protein Organization

6.5K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
6.5K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

10.9K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
10.9K
Protein and Protein Structure02:15

Protein and Protein Structure

79.6K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
79.6K
Protein and Protein Structures02:15

Protein and Protein Structures

10.5K
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相关实验视频

Updated: Jul 11, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

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2024年AlphaFold蛋白质结构数据库:为超过2.14亿个蛋白质序列提供结构覆盖.

Mihaly Varadi1, Damian Bertoni1, Paulyna Magana1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.

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概括
此摘要是机器生成的。

现在AlphaFold数据库提供了超过2.14亿个预测的蛋白质结构,大大扩大了结构生物学资源. 改进包括新的数据集,改进的数据访问和升级的可视化工具.

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科学领域:

  • 结构生物学 结构生物学
  • 生物信息学是一种生物信息学.
  • 人工智能在生物学中的应用

背景情况:

  • 阿尔法数据库 (AlphaFold DB) 通过人工智能驱动的蛋白质结构预测,彻底改变了结构生物学.
  • 2021年的初始发布包含了30万个结构;现在超过2.14亿.
  • AlphaFold DB预测被集成到主要的生物数据库中,如UniProt和PDB.

研究的目的:

  • 详细介绍AlphaFold数据库的扩展和增强.
  • 描述新的数据发布,访问方法和改进的服务.
  • 为了突出人工智能预测的蛋白质结构日益增长的影响.

主要方法:

  • 存档连续的AlphaFold DB版本,包括模型生物和全球健康蛋白质.
  • 整合精选蛋白质数据集和瑞士-Prot.
  • 开发各种数据访问机制:FTP,谷歌云公共数据库和程序端点.

主要成果:

  • 扩展到超过2.14亿个预测的蛋白质结构.
  • 包括各种数据集,如模型生物,全球健康蛋白质和瑞士-Prot.
  • 增强数据访问和改进的用户工具,包括预测对齐错误查看器和3D查看器.

结论:

  • AlphaFold数据库已成为结构生物学研究中不可或缺的资源.
  • 持续更新和服务改进可以提高数据的可访问性和实用性.
  • 该数据库展示了人工智能在生物发现中的变革力量.