英国狗的渐进性性角膜炎:微生物分离物,抗菌素敏感性和耐药性模式
Robert Goss1, Vicki J Adams2, Christine Heinrich1
1Eye Veterinary Clinic, Herefordshire, UK.
Veterinary ophthalmology
|November 7, 2023
概括
狗狗进展性性角膜炎中常见的细菌是Streptococcus canis,Pseudomonas aeruginosa和Staphylococcus pseudintermedius. 这些细菌是最常见的. 由于对单个抗微生物药物的敏感性和耐药性各异,建议进行组合治疗.
科学领域:
- 兽医眼科医生 兽医眼科医生
- 狗的传染病 狗的传染病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 狗慢性性角膜炎 (PUK) 是一种严重的眼部疾病.
- 识别致病原体及其抗生素敏感性对于有效治疗至关重要.
研究的目的:
- 为了识别与犬类PUK相关的细菌病原体.
- 为了确定这些分离物的抗微生物敏感性概况.
- 为英国犬类PUK的治疗策略提供信息.
主要方法:
- 微生物培养和敏感性数据的回顾性分析.
- 在英国的转诊诊所 (2018年12月 - 2020年8月) 从患有PUK的狗身上采集的样本.
- 鉴定细菌分离物和评估耐药性/敏感性模式.
主要成果:
- 在54%的狗中发现了细菌病原体.
- 最常见的分离物: 狗型链球菌 (Streptococcus canis), 伪菌 (Pseudomonas aeruginosa), 伪中间体的葡萄球菌 (Staphylococcus pseudintermedius).
- 对尼奥米辛 (85%),酸 (78%) 和四环素 (68%) 观察到显著的耐药性.
- 对珍塔米辛 (88%),奥洛素 (77%) 和西普洛素 (73%) 的高敏感性.
- 组合疗法 (例如,氨基/氨基与诺基诺) 在体外显示>90%的疗效.
结论:
- 狗菌, Pseudomonas aeruginosa 和 Staphylococcus pseudintermedius 是犬类PUK的主要病原体.
- 多样化的抗微生物敏感性和体外耐药性突显出单一治疗的局限性.
- 建议结合抗微生物治疗,等待培养和敏感性结果.
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