在检测大动脉狭窄症中的血N-终端亲B型尿素
Elisa Koljonen1, Laura Lappalainen1, Sanna Kotiranta1
1Heart Center, Kuopio University Hospital, Finland.
Scandinavian journal of clinical and laboratory investigation
|November 7, 2023
概括
血NT-proBNP水平可以帮助区分主动脉狭窄症 (AS) 和主动脉硬化症 (ASc) 在患有缩的老年患者中. 在AS患者中,增加的NT-proBNP水平显著更高,在排除其他疾病时有助于诊断.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 膜心脏疾病 膜心脏疾病
背景情况:
- 老年人的缩声往往起源于主动脉,通常是由于主动脉狭窄症 (AS) 或主动脉硬化症 (ASc).
- 心声图是当前区分AS和ASc的标准.
- 已知血N-终端 (NT) 亲激素BNP (NT-proBNP) 与AS严重程度相关.
研究的目的:
- 评估血NT-proBNP在区分AS和ASc的有用性.
- 确定NT-proBNP水平是否可以作为AS的诊断生物标志物.
主要方法:
- 一项涉及三个组的比较研究:AS患者 (n=87),ASc患者 (n=76) 和健康对照 (n=101).
- 所有参与者都接受了胸前心声学和血NT-proBNP测量.
- 排除标准包括已知增加NT-proBNP的疾病.
主要成果:
- 与ASc患者 (96 ng/l) 和对照组 (50 ng/l) 相比,ASc患者的血NT-proBNP显著更高 (中位数为413 ng/l) (p < 0.001).
- 经过对混因素的调整后,NT-proBNP仍然是一个显著的差异化指标 (p < 0.002对于AS和ASc).
- 接收器运行特征分析显示,NT-proBNP用于识别AS的曲线下面面积为0.878,最佳切线为115 ng/l.
结论:
- 血NT-proBNP是一种敏感的生物标志物,用于识别AS.
- 在没有混条件的情况下,NT-proBNP可用于排除患有缩的患者的AS,前提是没有混条件.
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