相关实验视频

Updated: Jul 11, 2025

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

葡萄种子的氨基素通过调节肠道微生物群和胆酸成分来改善狗的肠道炎症

Mingrui Zhang¹, Ruixia Mo¹, Haotian Wang¹

¹State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, People's Republic of China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|November 7, 2023

概括

葡萄种子的益桑托基亚尼丁 (GSP) 可以通过改善肠道细菌和胆酸代谢来缓解犬类炎症性肠病 (IBD). 便微生物群移植证实了GSP的存在.

科学领域:

兽医医学兽医医学兽医医学
胃肠病学胃肠病学
微生物学微生物学

背景情况:

狗炎症性肠病 (IBD) 提出了治疗挑战,预后不佳.
营养干预措施,特别是植物多,对狗肠道健康有希望.
葡萄种子的普朗索亚尼丁 (GSP) 是一种天然的多,具有潜在的治疗应用.

研究的目的:

评价葡萄种子益氨酸胺 (GSP) 在管理轻度犬类IBD.的疗效.
调查GSP对肠道炎症,透性和肠道微生物群的影响.
阐明肠道微生物群和胆酸代谢在GSP治疗效果中的作用.

主要方法:

实验1:向轻度IBD的拉布拉多犬给予GSP,评估炎症标志物和肠道透性.
实验1:分析便微生物群的组成和向代谢因子,以确定胆汁酸的样本.
实验2:从GSP治疗的狗中移植便微生物群到IBD的狗中,以证实作用机制.

主要成果:

在患有轻度IBD的狗中,GSP显著降低了肠道炎症,并降低了肠道透性.
GSP调节了肠道微生物群,增加了Ruminococcaceae和Faecalibacterium等有益的细菌.
观察到便中氧化酸和石化酸的升高,这表明在减少炎症方面发挥了作用.
从GSP治疗的狗身上移植的便微生物群复制了治疗效果,证实了微生物的作用.

结论:

葡萄种子的普兰托西亚尼丁 (GSP) 通过调节肠道微生物群和增强胆汁酸代谢,有效地减轻狗的IBD.
肠道微生物组成和功能的改变是GSP有效性的关键机制.
GSP代表了一种有前途的基于天然多的饮食策略,用于改善狗肠道健康和控制IBD.

关键词:

在 GSP 中,GSP 是一个普遍的标准.胆汁酸胆汁酸胆汁酸狗类犬类动物狗类犬类我们的肠道微生物群.肠道炎症是一种肠道炎症.

更多相关视频

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

相关概念视频

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...

Inflammatory Bowel Disease IV: Pharmacological Management

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

What is Monogastric Digestion?

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.