在冠状动脉心脏病中circRNA的诊断价值:一个元分析
Ming-Zhu Li1, Jia-Nan Zhang2, Fei Ren1
1Department of Cardiology, The First People's Hospital of Lianyungang, Lianyungang, 222002, Jiangsu PR, China.
Biomarkers in medicine
|November 7, 2023
概括
循环RNAs (circRNAs) 显示出作为冠心病 (CHD) 的诊断生物标志物具有前途. 这一元分析证实了他们的潜力,CHD诊断的曲线下的聚合面积为0.80.
科学领域:
- 生物标志物和诊断方法
- 心血管研究研究心血管研究
- 分子生物学分子生物学
背景情况:
- 循环RNAs (circRNAs) 越来越多地被认为是它们在各种疾病中的作用.
- 以前的研究表明,circRNAs可能有助于诊断冠心病 (CHD),但它们的诊断效果不一致.
- 需要进行全面的评估,以评估circRNAs对心脏病的诊断价值.
研究的目的:
- 进行元分析,评估冠状动脉心脏病 (CHD) 的circRNAs诊断精度.
- 巩固关于circRNAs作为潜在的CHD检测生物标志物的现有证据.
主要方法:
- 在PubMed,Web of Science和MEDLINE进行了系统的文献搜索.
- 包括16项研究,涉及3962名参与者 (2239例心血管疾病病例,1723例对照).
- 计算的聚合灵敏度,特异性,总结接收器操作特征 (SROC) 曲线,曲线下的面积 (AUC),正概率 (PLR) 和负概率 (NLR).
主要成果:
- 分析结果显示,在诊断CHD时,circRNAs的AUC为0.80.
- 聚合灵敏度和特异性分别计算为0.77和0.68.
- 进行了进一步的诊断指数计算,以评估整体性能.
结论:
- 循环RNA显示出作为冠状动脉心脏病 (CHD) 诊断的有效生物标志物的潜力.
- 这些发现支持circRNAs在临床环境中用于CHD诊断的实用性.
相关概念视频
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
18
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
18
01:30Acute Coronary Syndrome III: Diagnostic Studies
9
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
9
01:30Coronary Artery Disease I: Introduction
17
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
17
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
98
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
98
01:27Coronary Artery Disease V: Interprofessional Care
9
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
9
01:26Coronary Artery Disease IV: Preventive Measures
23
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
23