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混合闭环系统对1型糖尿病患者用传感器增强治疗的血糖控制和心理方面的影响:一项前性单中心观察研究
Tomoaki Akiyama1, Tadashi Yamakawa1,2, Kazuki Orime1
1Department of Endocrinology and Diabetes, Yokohama City University Medical Center, Yokohama, Japan.
Journal of diabetes investigation
|November 7, 2023
概括
梅特罗尼克MiniMed 770G混合闭环系统改善了1型糖尿病患者的血糖控制,减少了高血糖和低血糖. 然而,与以前的系统相比,它并没有显著改善心理健康.
科学领域:
- 内分泌学 在内分泌学.
- 医疗器械 医疗器械
- 糖尿病 技术 技术
背景情况:
- 1型糖尿病的管理需要持续的葡萄糖监测和胰岛素输送.
- 混合闭环系统旨在自动化血糖控制,可能改善结果.
- 像MiniMed 640G这样的先前系统提供了预测性低葡萄糖暂停功能.
研究的目的:
- 评估Medtronic MiniMed 770G混合闭环系统对1型糖尿病的血糖控制的影响.
- 评估与770G系统相关的心理方面,包括满意度,痛苦和生活质量.
- 为了比较770G系统的性能与MiniMed 640G预测低葡萄糖悬浮系统.
主要方法:
- 一项为期3个月的前性观察性研究,涉及22名1型糖尿病患者.
- 参与者从MiniMed 640G系统过渡到MiniMed 770G系统.
- 血糖控制通过时间范围 (70-180 mg/dL) 和HbA1c水平进行评估. 用验证的问卷进行心理方面的测量.
主要成果:
- 范围内的时间 (63.5%至73.0%) 显著改善,范围以上时间减少 (26.9%至19.6%).
- 糖化血红蛋白 (HbA1c) 的降低,从7.7%降至7.2%.
- 低于范围的时间增加了<4% (91%至100%),表明降低了低血糖症. 心理测量没有显著变化,与增加的传感器校准相关的潜在恶化.
结论:
- MiniMed 770G混合闭环系统有效降低1型糖尿病的高血糖和低血糖.
- 与预测性低葡萄糖暂停系统相比,心理结果没有改善.
- 增加传感器校准频率可能会对情绪困扰和生活质量产生负面影响.
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