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一种聚乙烯比古安化组装辅助的牙结合策略极大地促进了结合效应和牙治疗

Chang Shu¹, Yadong Chen¹, Zhenzhen Zhang¹

¹Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, P. R. China. luoqiaojie@zju.edu.cn.

Journal of materials chemistry. B

|November 7, 2023

概括

这项研究引入了一种新的牙粘合策略,使用聚甲基比古安化物 (PHMB) 来改善非矿物化牙矩阵 (DDM) 接口. 这种方法增强了粘合剂的透性,并提供抗菌性质,减少了二次.

科学领域:

生物材料科学生物材料科学
牙科材料牙科材料
纳米技术纳米技术

背景情况:

牙修复中混合层的结构性退化会损害结合,导致二次.
目前的策略未能同时解决杂交层中的粘合剂透和细菌感染.

研究的目的:

开发使用聚乙烯比古安化物 (PHMB) 的非矿化牙矩阵 (DDM) 的接口重建的粘合策略.
为了增强粘合剂的透性,并为混合层提供固有的抗菌特性.

主要方法:

广谱杀菌PHMB的静电组合到阴性3D DDM上,形成PHMB/DDM复合体.
描述DDM表面潜力,离子含量和接口水含量的变化.
在热循环老化后对粘合强度的评估以及对生物膜的抗菌性质的评估.

主要成果:

通过PHMB处理,DDM表面电位增加了100mV,阴离子含量减少了20%,接口水减少了40%,从而促进了粘合剂的透.
在热循环后,PHMB组的结合强度是对照组的1.451.65倍.
治疗PHMB证明了杀死细菌的能力,并减少了细菌的粘附性,延迟了二次.

结论:

PHMB治疗有效地重建了DDM接口,创建了一个缺陷低的,固有的抗菌混合层.
这一策略提高了结合的有效性,增强了牙治疗,并有助于预防二次牙.

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