预测器和预后的气管切除术在复发性多重合体炎
Ruxue Yin1, Dong Xu1, Qian Wang1
1Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing, China.
复发性多重合体炎患者的喉参与可能需要气管切除术. 年轻或老年患者,喉支气管胀和肺部感染是这种呼吸道干预的关键风险因素.
科学领域:
- 医学研究 医学研究
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 复发性多重合体炎 (RP) 可能会导致气道阻塞,特别是喉受影响.
- 气管切除术可能是必要的,以管理严重的呼吸道并发症在RP患者.
- 鉴定气管切除术的危险因素对于积极的患者管理至关重要.
研究的目的:
- 确定复发性多重体炎和喉干扰患者气管切除术的独立风险因素.
- 开发和验证气管切除风险的预测模型 (nomogram).
- 评估气管切除术对短期和长期生存率的影响.
主要方法:
- 对232名复发性多合体炎患者的回顾性审查,重点关注146名喉受影响的患者.
- 多变量后勤回归分析以确定气管切除术的风险因素.
- 使用C-index和引导重抽样开发和验证一个名ogram.
- 决策曲线分析以评估名图的临床实用性.
主要成果:
- 在146名喉受损患者中,有21名患者需要进行气管切除术.
- 气管切除术的独立风险因素包括年龄≤25或≥65岁,喉支气管胀和肺部感染.
- 开发的名图表显示出高的预测准确性 (C指数为0.936) 和歧视力.
- 气管切除术与增加住院死亡率有关,但与长期存活率无关.
结论:
- 一个名图有效地预测了气管切除术风险在复发性多重合体炎患者的喉参与.
- 早期识别高风险个体可以指导临床决策和资源分配.
- 虽然气管切除术增加了短期死亡率,但它不会影响这个群体的长期存活.
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