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西不会诱导敏感性标记HSP70在神经元易受奥尔尼病变的神经元

Ana-Maria Iorgu¹, Andrei-Nicolae Vasilescu², Natascha Pfeiffer²

¹Department of Psychiatry and Psychotherapy, Research Group Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany. ana-maria.iorgu@uni-heidelberg.de.

European archives of psychiatry and clinical neuroscience

|November 7, 2023

概括

赛洛西宾是一种血清素受体激动剂,与S-ketamine不同,它不会在老鼠大脑中引起神经毒性. 这表明psilocybin可能是一个更安全的抗抑郁药选择,避免与NMDAR对抗剂相关的神经元损伤.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
毒理学毒理学毒理学

背景情况:

S-胺和西是快速起作用的抗抑郁药.
两者都增加了谷氨酸信号传递和皮质过度兴奋.
S-胺会引起神经毒性,特别是在后皮层.

研究的目的:

调查psilocybin是否诱导类似于S-ketamine的神经毒性作用.
为了比较psilocybin和S-ketamine在大脑中的神经毒性潜力.
评估关于神经元损伤的psilocybin的安全性.

主要方法:

在老鼠中,对热冲击蛋白70 (HSP70) 的免疫组织化学全脑映射.
治疗组包括了psilocybin,S-ketamine和MK-801.
分析的重点是神经元表达HSP70,这是细胞应激的标志物.

主要成果:

在接受S-胺和MK-801治疗的老鼠的后皮质中检测到HSP70阳性神经元.
在接受了 псилоцибин治疗的老鼠的后皮质中没有观察到 HSP70 阳性神经元.
这表明,在这个大脑区域缺乏西诱导的神经毒性.

结论:

西似乎不会引起与S-ketamine观察到的特定神经毒性作用.
在临床抗抑郁药的使用中,psilocybin可能是S-ketamine更安全的替代品.
需要进一步的研究,以充分阐明psilocybin的神经毒性特征.

关键词:

抗抑郁药是一种抗抑郁药.在HSP70中,HSP70是胺基氨酸 (ketamine) 是一种可以奥尔尼的病变是奥尔尼的病变.这种药物是psilocybin.

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