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量化夜间尿性淋巴激素分泌预测女孩即将发生青春期:一项半纵向研究

And Demir¹, Atilla Büyükgebiz², Adem Aydin³

¹Pediatric Research Center, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Biomedicum 2 C, 6th Floor, Tukholmankatu 8 A, FIN-00290, Helsinki, Finland. drand@demir.net.

Hormones (Athens, Greece)

|November 7, 2023

概括

第一天早上排尿时,黄素激素 (LH) 和卵泡刺激激素 (FSH) 的度可以预测青春期的开始. 尿液中的LH和FSH水平在一夜之间发生的变化为青春期的发展和即将到来的初潮提供了洞察力.

科学领域:

生殖内分泌学生殖内分泌学
儿科内分泌学儿科内分泌学
尿液生物标志物分析

背景情况:

评估青春期发育通常涉及侵入性荷尔蒙测试.
尿性淋巴激素测量为监测青春期提供了一个非侵入性的替代方案.
了解性腺激素的夜间变化可以提供GnRH脉冲生成器活动的见解.

研究的目的:

评估第一天早上空白 (FMV) 和昨晚空白 (LNV) 尿液淋巴激素度作为青春期开始的预测指标.
为了探索尿路素激素 (LH) 和卵泡刺激激素 (FSH) 的夜间折叠变化的实用性,作为GnRH刺激测试的替代品.
确定尿路LH和FSH的切断值,以预测一年内青春期的临床症状.

主要方法:

调查了30名女孩在青春期前和青春期期间尿液LH和FSH免疫活性的夜间变化.
收集了FMV和LNV的尿样进行分析.
利用接收器操作特征 (ROC) 分析来确定激素度和比率的预测值.

主要成果:

FMV LH和FSH度分别高于0.3 IU/L和2.5 IU/L,准确地预测了青春期的开始 (100%的灵敏度和特异性).
超过0.8 IU/L的FMV LH度表明了青春期的临床迹象.
在LH和LH/FSH比率的夜间增加 (FMV/LNV比率) 预测了青春期阶段和即将到来的初潮.

结论:

FMV尿液中的LH和FSH水平作为可靠的,非侵入性的标志物,用于预测一年内青春期的开始.
特定的FMV LH度可能反映了GnRH脉冲发生器的调节.
一夜间尿液LH和LH/FSH比率的变化可能表明即将到来的初潮,这需要进一步的纵向研究.

关键词:

第一个早晨被撤销的空白.卵泡刺激激素是一种激素.昨天晚上的空白.流化激素的作用是什么?青春期的开始青春期的开始尿道性腺激素 (Urinary gonadotropin) 是一种尿道性腺激素.

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