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基因验证PfFKBP35作为一种抗疟疾药物标

Basil T Thommen1,2, Jerzy M Dziekan3, Fiona Achcar4,5

  • 1Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.

eLife
|November 7, 2023
PubMed
概括

向Plasmodium falciparum FKBP35对疟疾寄生虫具有致命作用,导致蛋白质合成停滞. FK506的抗增殖活性是独立于PfFKBP35的,这表明了替代药物标.

关键词:
这就是CETSA.在FK506中使用.结合FK506的蛋白质在 FKBP3535 的位置上.在P. falciparum的研究中.原菌 (Plasmodium falciparum) 是一种有毒的病毒.这是一种抗疟疾药物.传染病是一种传染性疾病.微生物学的微生物.

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